From myth and ancient history through to modern medicine, research continues to support the far reaching benefits of the Pomegranate ‘Tree of Life’.
Scientists from around the world continue to research the therapeutic properties of the pomegranate, exploring its benefits for many conditions and illnesses. They now know that the wonders of the pomegranate can be found in just a single drop of precious seed oil.
The following links to independent studies and research articles contain promising findings that are beginning to substantiate the celebrated benefits of the pomegranate. The following published papers are provided for information only.
Anticancer activities of pomegranate extracts and genistein in human breast cancer cells.
Jeune MA, Kumi-Diaka J. Brown J. Journal of Medicinal Food 8(4): 469-75 (December 2005)
Pomegranate Extracts Potently Suppress Proliferation, Xenograft Growth, and Invasion of Human Prostate Cancer Cells
Martin Albrecht, Wenguo Jiang, James Kumi-Diaka, Ephraim P. Lansky, Lyndon M. Gommersall, Amit Patel, Robert E. Mansel, Ishak Neeman, Albert A. Geldof, Moray J. Campbell. Journal of Medicinal Food. 2004, 7(3): 274-283.
Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.
Aslam MN, Lansky EP, Varani J. Journal of Ethnopharmacology 103: 311-18. (February 2006)
Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer.
Lansky EP, Newman RA. Journal of Ethnopharmacology 109(2): 177-206 (January 2007)
Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum
L. Reddy MK, Gupta SK, Jacob MR, Khan SI, Ferreira D. Planta Medica. 73(5): 461-7. (May 2007)
Pharmacological and therapeutic properties of pomegranate.
Lansky E, Schubert S, Neeman I. I Symposium International Sobre El Granado [First International Symposium on the Pomegranate], Orihuela, Spain, 15-17 (October 1998).
Antioxidant and Eicosanoid Enzyme Inhibition Properties of Pomegranate Seed Oil and Fermented Juice Flavanoids
Shay Yehoshua Schubert, Ephraim Philip Lansky, Ishak Neeman. Journal of Ethnopharmacology 66 (1999) 11-17.
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer.
Kim ND, Mehta R, Yu W, et al. Breast Cancer Research and Treatment. 71(3): 203-17 (February 2002)
Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD Mice
Justin J. Hora, Emily R. Maydew, Ephraim P. Lansky, and Chandradhar Dwivedi. Journal of Medicinal Food, 6 (3) 2003, 157-161
New Developments in the Realm of Complementary Medicine: First International Conference of the Society of Integrative Oncology.
Cassileth Barrie R., PhD Memorial Sloan-Kettering Cancer Center, New York, New York. Journal of Supportive Oncology. 3 (3): (May/June 2005)
Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice.
Yamasaki M, Kitagawa T, Koyanagi N, Chujo H, Maeda H, Kohno-Murase J, Imamura J, Tachibana H, Yamada K. Nutrition. 22(1):54-9. (January 2006)
Punica granatum: Heuristic treatment for diabetes mellitus.
Katz, S.R., Newman, R.A., Lansky, E.P. Journal of Medicinal Food 10: 213-7. (2007)
Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum
L. Reddy MK, Gupta SK, Jacob MR, Khan SI, Ferreira D. Planta Medica. 73(5): 461-7. (May 2007)
Preliminary Studies on the Anti-Angiogenic Potential of Pomegranate Fractions in Vitro and in Vivo
Masakazu Toi, Hiroko Bando, Cheppail Ramachandran, Steven J. Melnick, Atsushi Imai, Rose S. Fife, Raymond Eric Carr, Tsutomu Oikawa & Ephraim Philip Lansky. Angiogenesis 6: 121-128, 2003.
Pomegranate (Punica granatum) Pure Chemicals Show Possible Synergistic Inhibition of Human PC-3 Prostate Cancer Cell Invasion Across Matrigel
Ephraim Philip Lansky, Gregory Harrison, Paul Froom and Wen G. Jiang. Investigational New Drugs 23: 121-122, 2005.
Possible Synergistic Prostate Cancer Suppression by Anatomically Discrete Pomegranate Fractions
Ephraim P. Lansky, Wenguo Jiang, Huanbiao Mo, Lou Bravo, Paul Froom, Weiping Yu, Neil M. Harris, Ishak Neeman and Moray J. Campbell. Investigational New Drugs 23: 11-20, 2005.
Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids.
Schubert SY, Lansky EP, Neeman I. Journal of Ethnopharmacology 66: 11-17. (July 1999)
Pomegranate seed oil rich in conjugated Linolenic acid suppresses chemically induced colon carcinogenesis in rats. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Cancer Science - The Official Journal of the Japanese Cancer Association 95(6): 481-6 (June 2004);
Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. van Elswijk, D.A., Schobel, U.P., Lansky, E.P., Irth, H., van der Greef, J., Phytochemistry 65: 233-41. (2004)
Pomegranate May Be Helpful in Fighting Breast Cancer.
News from Breast Cancer Week; Vol. 1 No. 31. (August 26, 2001)